Acid-Sensing Ion Channels: Structure and Function
نویسنده
چکیده
The ASIC channels constitute a subfamily within the larger ENaC superfamily. Despite the fact that the ASICs share only about 20-25% identity with the ENaC channels they display all the characteristics of the superfamily, which are, two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functional channel of the superfamily is composed of 4 subunits. In the case of the ASICs, the channel can be either a homo or heterotetramer that will result in different functional properties. Another shared characteristic of ASICs and ENaCs is their sensitivity to low concentrations of amiloride, a widely used diuretic.
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تاریخ انتشار 2004